This paper deals with the development of water quality in the Elbe in the section between its confluence with the Vltava and the Hřensko border profile in 1980–2020, and with the influence of Prague on its pollution levels. After a significant improvement in 1985–2000, the quality of water discharged through the Hřensko profile today is at least at the level of the Federal Republic of Germany. Evaluation of substance transport shows that the Vltava contributes a larger share of pollution to the Elbe simply because it has higher flows. Prague contributes to pollution of the Vltava and the Elbe by discharging phosphorus.
As for other long-term indicators, it is an insignificant source.
In 2010–2020, there is a significant level of concentrations of pharmaceuticals, which come exclusively from the discharge of municipal wastewater treatment plants (WWTP). Many pharmaceuticals regularly occur in concentrations of tens to hundreds of [ng/l], and resistant pharma-ceuticals (gabapentin, metformin, oxipurinol, carbamazepine) are transported to Prague from the Vltava basin through the Orlík and Slapy reservoirs with a high theoretical retention time. The transport of resistant pharmaceuticals through relevant profiles corresponds mainly to the number of inhabitants in their river basins because they obviously pass through WWTP and do not degrade further in the river either.
During 2011–2015 we have studied water springs remaining in big cities. The main objective was verifying the possibility of using local springs as local sources of water in risk situations as failures of water or energy supply systems.